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Tissue-Resident Memory T Cells
Fathia Mami-Chouaib, Eric Tartour
Frontiers Media SA · 2019
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Theological soundness · worldview · content
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Tissue-resident memory T (TRM) cells play a major role in control of viral infections.
Their involvement in cancer diseases has been more recently demonstrated. This
non-circulating T-lymphocyte subset lacks molecules enabling egress from the
tissue and migration to lymph nodes, expresses specific markers of residency and
displays specific transcription factors. The present special issue elucidates our current
knowledge on CD8+ TRM cells and explores less frequently described resident
subsets, such as CD4+ TRM and innate-like cells, as well as their specific metabolism
and niches for their formation in infectious and cancer diseases.
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